Kinetics of butyrylcholinesterase inhibition by an ethanolic extract of Shorea robusta
نویسندگان
چکیده
Purpose: Cholinesterase inhibitors are the class of compounds which inhibit cholinesterase enzyme. These are used as drugs for symptomatic treatment of Alzheimer’s disease (AD). The present study, evaluate antibutyrylcholinestease property of ethanolic extract of Shorea robusta de oil cake (DOC). Method: Ellman’s method was used to determine the butyrylcholinesterase (BuChE) enzyme inhibitory activity by an ethanolic extracts of Shorea robusta de oil cake (DOC). Results: In present study, Shorea robusta DOC showed concentration dependent BuChE inhibition by an ethanolic extracts of Shorea robusta with maximum inhibition (63.11±0.09%) at 200μg/ml final concentrations. The Lineweaver-Burk plot of an ethanolic extract of Shorea robusta DOC showed mixed non-competitive mode of inhibition. Conclusion: The anti BuChE enzyme activity exhibited by an ethanolic extracts of Shorea robusta DOC extracts might be used in future for symptomatic treatment of AD.
منابع مشابه
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